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Thank you for submitting a Full Application for the SU2C-CRUK Pediatric Cancer New Discoveries Challenge. The Team leader will receive an email shortly confirming your submission.

The next step in the process is for the SU2C Science Team to review the Full Application for completeness and clarity. You will be contacted shortly if the SU2C Science Team has any questions about your application; otherwise, you will be informed when your application has been assigned to Reviewers. The next step in the process is that the Steering Subcommittee will select the Teams to invite for the in-person Selection Meeting on March 3-5, 2020, in Los Angeles to include the Team Leader and Team Co-Leader. Please hold this date on your calendar. Please contact Dr. Cathy Higgins at chiggins@su2c.org if you have any comments or questions about the process. Thank you again for your interest in the SU2C-CRUK Pediatric Cancer New Discoveries Challenge.

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SU2C-CRUK PEDIATRIC CANCER
NEW DISCOVERIES CHALLENGEAPPLICATION SUBMISSION SITE

Call for Applications:

Stand Up To Cancer (SU2C) and Cancer Research UK (CRUK) invite applications for the SU2C-CRUK Pediatric Cancer New Discoveries Challenge: a new, focused effort to spark novel approaches and new collaborations from investigators both within and outside the field of pediatric cancer research, with the ultimate aim of increasing the number of innovative and effective approaches to treating pediatric cancer. This program will support collaborative, multidisciplinary, multi-institutional, trans-Atlantic Teams to pursue a step-change in our understanding of the drivers of pediatric cancers and the development of novel or repurposed medicines, treatment strategies or technologies. With a clear and rational line of sight to the clinic, these projects will have the potential to significantly impact pediatric cancer patients, including teenagers and young adults. Applicants are strongly encouraged to form teams that include expertise beyond pediatric oncology (e.g. other areas of oncology, biology, chemistry, engineering, physics, etc.) and investigate one or more of the following concepts, with the goal of progressing the approach to a more advanced pre-clinical or clinical setting in round 2:

  • the basis of tumor initiation and progression,
  • novel therapeutic approaches,
  • development of novel biomarkers or methodologies to predict disease progression, to enhance efforts in primary and secondary prevention and intervention,
  • novel models that would enhance pre-clinical research,
  • development of more effective and/or less toxic treatments to improve long-term health and quality of life.

We would welcome proposals that advance research in any type of pediatric cancer, particularly inviting new proposals in pediatric brain tumors.

Proposed ideas should be based on perceived opportunities for success as well as the potential to address an area of critical patient need.

The Pediatric Cancer New Discoveries Challenge is expected to involve a two-step approach that will provide initial, short-term funding to a number of applicants (Round 1), followed by additional funding for a subset of Round 1-funded Teams (Round 2) for more advanced pre-clinical or clinical studies. More details on the two Rounds are as follows:

Round 1

  • The first round of funding will support studies to discover new biological mechanisms underpinning pediatric cancers or to evaluate a novel or repurposed medicine, treatment strategy or technology for use in pediatric cancer treatment.
  • Proposed studies will include clear milestones for success and articulate a clear line of sight to clinical utility.
  • $1 million awards with a 24-month term will be provided to successful applicants.
  • Awardees will be asked to execute contracts and sub-contracts by July 1, 2020.
  • Teams will be required to submit scientific progress reports and to attend an in-person review meeting every six months throughout the grant term.
  • Awardees will be required to submit a written progress report, and, if appropriate, a proposal for Round 2 funding 18 months after the beginning of the grant term.

Round 2

  • The second round of funding is expected to support further pre-clinical or clinical studies of the most promising Teams from Round 1.
  • Proposed studies will contain milestones and deliverables, as appropriate for the type of research study, including the anticipated translational objectives, as well as a clinical trial recruitment plan where appropriate.
  • It is anticipated that awards with a 3 or 4-year term will be provided to successful applicants, with the award amount dependent on the nature and scale of the research study.
  • The composition of the selected Teams in Round 1 may be expanded for Round 2 to include additional expertise.
  • Teams will be required to submit scientific progress reports and to attend an in-person review meeting every six months throughout the grant term.
  • Teams will be required to submit a monthly clinical trial report for all open trials, where appropriate.

Round 2 funding will be supported in part by No More Kids with Cancer.

Application Deadlines: An Intent to Submit form must be completed on or before December 6, 2019. Applications for Round 1 funding must be submitted on or before January 10, 2020. See page 11 of the Program Guidelines and Application Instructions for Full Proposal submission instructions. An in-person Selection Meeting will be held in Tuesday, March 3, 2020, in Los Angeles, California, requiring a presentation by the Team Leader and Co-Leader.

Applications: The application includes a text application template and spreadsheet templates for completion and submission. The spreadsheet templates include: (1) Milestones and Deliverables Timeline, (2) Requested funding and required regulatory approvals per Specific Aim, (3) Budget per year and per Institution, and (4) Personnel Tracker. Collaborative groups of researchers from diverse institutions are preferred, and all applications must include inter-institutional collaborations. Curriculum vitae (NIH Biosketch preferred but not required) with a recent (five year) publication list, as well as current funding, should be included for Team Leadership (Team Leader, Team Co-Leader, and Team Principal Investigators). Teams are required to have a Team Leader and a Team Co-Leader. There are no citizenship or residency status restrictions for team members; however, the Team Leader or Team Co-Leader must be UK-based. Teams must include a Project Manager and at least two Patient Advocates. Letters of Support from leadership at each institution and company involved with the Team are required. If a clinical trial is proposed, then a clinical trial protocol or a compelling justification for delaying the protocol development will be required.

Notification: The Finalists for Round 1 funding will be informed on or around February 15, 2020. An in-person Selection Meeting to interview the Finalists will be held on March 3-5, 2020, in Los Angeles, California. Awardees of Round 1 funding will be notified on or around April 1, 2020, and asked to execute contract by July 1, 2020. Awardees interested in applying for Round 2 funding will be required to submit a written progress report and proposal by January 10, 2022.

If you have questions, please contact proposals@su2c.org.

Program Guidelines and Application Instructions
Download
Intent To Submit Application

Must be completed and emailed to proposals@su2c.org prior to submitting the project application.

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Project Application

Completed applications must be uploaded on the left-hand side of this page under “Upload Project Applications.”

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Application Spreadsheets

Completed applications must be uploaded on the left-hand side of this page under “Upload Spreadsheets.”

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If you have questions, please contact us.