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Submit application by June 1, 2020, at 5pm Eastern Daylight Time

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The committee to choose teams and projects will rate the applications, estimate budgets, and each applicant will be notified by Sept/Oct 2017, for a projected start date of January 2018. All regulatory requirements will have to be in place before funding begins. In the fall of 2017, SU2C will hold a meeting of researchers funded for this set of projects. Prior to that meeting, we will explore possible collaborations with computer science researchers involving machine learning, and other advanced statistical methods for analysis of large complex data sets.

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Convergence 3.1416 Call for Ideas

Convergence 3.1416 Goal

Applications Requested for Stand Up To Cancer (SU2C) Convergence Grants Exploring Cancer’s Communications among the Immune System and the Microbiome Using Organoids and Mice.

Goal: develop a set of experimental platforms using organoid systems in vitro, and mouse models, that will permit a detailed exploration and understanding of the interactions and chemical communications among the cancerous/normal organoid, the immune system, and the microbiome.

Convergence 3.1416 aims to bring together research laboratories with complementary skill sets and technological approaches:

  • Laboratories able to make and maintain organoids from multiple types of human or mouse tissues;
  • Cellular immunologists exploring the innate immune system and the adaptive immune system;
  • Virologists and microbiologists who study the microbiomes of various tissues;
  • Individuals using mass spectroscopy to characterize changes in metabolism and to identify metabolites that act as signaling agents between organ systems;
  • Researchers who use multiplex mass spectroscopy of peptides to identify proteins that could be communicating among microbes, lymphocytes, and tissues of the body;
  • Engineers who can create “chemostats” for organoids and their fellow lymphoid and microbial travelers, with both aerobic and anaerobic compartments;
  • Quantitative biologists and physicists studying diffusion of nutrients and signals for communicating, who can analyze large data sets of information collected from sequencing, microscopy, and time lapse filming of cultures.

Applications: A letter of intent describing current research directions, capabilities, and a list of recent publications, information about present position, institution, and laboratory size and scope. Current funding should be included, as well as any conflicts of interest. Please submit your applications to StandUpToCancer.org/Convergence by June 1, 2020.

Notification: Applications will be screened by a committee, and it is anticipated that 10-15 investigators will be invited to a three day ideas laboratory to be held at the Institute for Advanced Study, in Princeton, New Jersey, at which invited investigators will give a short talk about their work and capabilities, and break up into groups to determine if collaborative efforts can be planned. Following this meeting, a subset of the group will be selected to write proposals of no more than 10 pages, and supply a budget for a three to four year grant period. The review committee will recommend which proposals are acceptable for funding.

If you have questions, please contact proposals@su2c.org